Understanding Genetics: DNA, Genes, and Their Real-World Applications

Rated 3 out of 5 by from Ancient history I was disappointed to learn the course was made back in 2008. For a new science like genetics that's a long time and it shows. The course needs to be updated; the company should send me some amendments to make the course timely. I may or may not recommend this to a friend--depends on the friend's knowledge base
Date published: 2020-09-07
Rated 5 out of 5 by from Loved this.I have no scientific background, just some belated curiosity and whilst much of it was a bit over my head I really enjoyed the way the content of each lecture was illustrated though stories and examples. The professor was great.
Date published: 2020-09-02
Rated 1 out of 5 by from Not good. I am here to learn genetics, not listen to corny jokes and talk on and on about the history of genetics, or other irrelevant topics. The history is important but he spends too much time on it, and other irrelevant topics. let people read about that in the suggested reading. Look for a better course on YouTube called "Genetics playlist"
Date published: 2020-08-31
Rated 5 out of 5 by from Understanding Genetics I wondered if I would be able to follow the content. So far it has been understandable, although very technical. I'm extremely happy to have bought this course.
Date published: 2020-07-10
Rated 5 out of 5 by from Very good I find this lecture course very educative and interesting.
Date published: 2020-06-15
Rated 5 out of 5 by from Great Course This is another great course with excellent lectures. This is a good way to accumulate more knowledge in an enjoyable experience.
Date published: 2020-06-14
Rated 5 out of 5 by from informative and entertaining Great couse and beats watching the news during these difficult Coronavirus times. Presentation was very well done by an outstanding Professor.
Date published: 2020-04-30
Rated 4 out of 5 by from Presents a good understanding I have viewed half the lectures so far and have found Dr. Sadava's method of teaching easy to understand and interesting by his use of relavant stories. I have studied some genetics back in 1978 while taking biochemistry and I wanted to update my basic knowledge. I feel that I am half way there and I found the history of genetics interesting as back in 78 we were learning some state of the art science.
Date published: 2020-02-05
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Our Inheritance
1: Our Inheritance

From earliest history, humans have bred plants and animals for desirable and productive characteristics. And they have wondered how it all works. Professor Sadava gives us a brief, fascinating history of genetics and introduces us to the three major unifying ideas in biological science, ideas which form the cornerstone of this course.

31 min
Mendel and Genes
2: Mendel and Genes

Monk and scientist Gregor Mendel, working in the late 1800s, learned through pea-plant experiments that each parent's characteristics were particulate, that is, chemically independent. His meticulous research-the beginning of modern genetics-languished for nearly 40 years before its value was discovered.

30 min
Genes and Chromosomes
3: Genes and Chromosomes

Where do you find a gene? Within each living cell is a nucleus, within the nucleus is a chromosome, and on that chromosome is the gene. Beginning with the cell, the unit of biological continuity, this lecture describes the physical and chemical environment of the gene. It shows us that you don't have to be a geneticist to figure out genetics, as a group of rabbis in A.D. 500 learned.

30 min
The Search for the Gene-DNA
4: The Search for the Gene-DNA

How did research on smoking and lung cancer help scientists figure out that DNA, the genetic material, was damaged in the tumor cells? Professor Sadava tells us how scientists first determined what they were looking for and then found the circumstantial evidence that pointed to DNA.

30 min
DNA Structure and Replication
5: DNA Structure and Replication

The double helix model for DNA is one of the most recognizable scientific icons of our time. This lecture details how Watson and Crick built on the work of earlier researchers to solve the puzzle of the structure of DNA-the double helix.

31 min
DNA Expression in Proteins
6: DNA Expression in Proteins

Proteins are made up of chains of 20 amino acids ordered in a particular sequence for each protein. Humans cannot produce eight of those 20 amino acids, although we still need them for proper nutrition. Professor Sadava explains what proteins are, how they relate to DNA, and why they're significant to us.

29 min
Genes, Enzymes, and Metabolism
7: Genes, Enzymes, and Metabolism

Enzymes, which are encoded in our genes, are responsible for most chemical conversions in our bodies. An enzyme sends a signal that creates a biochemical pathway for the process of changing something we consume into something else we need or must get rid of. This lecture explains how metabolism is hard-wired into our genes.

29 min
From DNA to Protein
8: From DNA to Protein

In 2004 traces of a poison called ricin were found in a U.S. Senate mailroom. Only 1/10,000 of an ounce of ricin can be fatal. Ricin's enzymes inhibit gene expression; as a result, when ricin is introduced to animal cells, the cells die. This lecture explains how gene expression happens.

30 min
Genomes
9: Genomes

The 24,000 genes that are expressed in humans represent only 2 percent of the entire genome. This lecture explains the history of the Human Genome Project, which grew out of scientists' studies on the effects of radiation on the survivors of the atom bombs in Hiroshima and Nagasaki.

31 min
Manipulating Genes-Recombinant DNA
10: Manipulating Genes-Recombinant DNA

By studying how bacteria successfully protect themselves from an attacking virus, scientists discovered that bacteria make an enzyme that recognizes a particular DNA sequence in the virus and cuts the DNA strand at that sequence. As a result of this discovery, scientists learned to splice DNA, creating recombinant DNA, which was initially controversial and now holds vast possibilities for the futu...

31 min
Isolating Genes and DNA
11: Isolating Genes and DNA

Learn how genetics is used to understand and work toward the cure of a particular disease. After methods for analyzing DNA and chromosomes were developed rapidly in the 1980s, the scientific community tried a new approach called reverse genetics. As a result of this work, scientists isolated the gene that is missing in individuals who have muscular dystrophy.

30 min
Biotechnology-Genetic Engineering
12: Biotechnology-Genetic Engineering

Insulin that treated individuals with diabetes, whose bodies don't create insulin (or enough of it) on their own, used to come from animals. Animal insulin, however, contains a different sequence of amino acids, so some people's bodies rejected it. The method of manufacturing insulin developed at a California hospital is how all insulin used to treat diabetics is now made.

30 min
Biotechnology and the Environment
13: Biotechnology and the Environment

We can use bacteria to solve man-made problems, such as landmines, oil spills, toxic waste, and pollution. Scientists are working to genetically engineer organisms whose traits can be useful in cleaning up our world.

30 min
Manipulating DNA by PCR and Other Methods
14: Manipulating DNA by PCR and Other Methods

What's the real science behind the dinosaurs that come to life in the movie Jurassic Park? Professor Sadava explains how scientists extract DNA from fossils, and what we can learn about ancient creatures from their genes. This lecture also covers DNA sequencing methods....

30 min
DNA in Identification-Forensics
15: DNA in Identification-Forensics

In the aftermath of the 2004 tsunami in Sri Lanka, hundreds of children were separated from their parents. When several couples were claiming one baby as their own, DNA testing enabled doctors to reunite the real parents with their baby. This kind of testing is frequently used in crime-solving today.

30 min
DNA and Evolution
16: DNA and Evolution

Charles Darwin's travels to the Galapagos Islands helped him understand that different species come from a common ancestor. This lecture explains the genetic components of Darwin's theories.

32 min
DNA and Human Evolution
17: DNA and Human Evolution

Sickle cell disease is more frequently found in African Americans than in Caucasians. After studying this incurable condition, scientists discovered that carriers of sickle cell disease were resistant to malaria, a far more life-threatening sickness. Why? In this lecture, Professor Sadava explores the role of genetic adaptation in human evolution.

31 min
Molecular Medicine-Genetic Screening
18: Molecular Medicine-Genetic Screening

How do scientists detect particular genes that cause certain diseases? Professor Sadava details chemical processes used for genetic screening, and gives several examples of successful genetic tests and results. He describes testing for the effects of genes on drug susceptibility as the next frontier in screening technology.

31 min
Molecular Medicine-The Immune System
19: Molecular Medicine-The Immune System

George Washington stemmed a smallpox epidemic by ordering his soldiers to be inoculated during an outbreak. Fifty years earlier, the slave Onesimus had advised Cotton Mather, the Puritan minister, of the practice in his homeland of rubbing dried pus from a smallpox carrier onto a cut of a healthy person. This process created antibodies that resisted the disease. Professor Sadava uses these illustr...

29 min
Molecular Medicine-Cancer
20: Molecular Medicine-Cancer

Cancer develops when cells lose control over their normally regulated reproduction. Only 10 percent of cancers are inherited, but it is a genetic disease. This lecture explains how cancer cells are created and how they can be treated.

30 min
Molecular Medicine-Gene Therapy
21: Molecular Medicine-Gene Therapy

So far gene therapy-the process of adding protein-coding DNA and a promoter sequence for its expression to an organism for medical benefit-has experienced some success in animals and small gains in humans. Professor Sadava shares cutting-edge research and experimentation.

31 min
Molecular Medicine-Cloning and Stem Cells
22: Molecular Medicine-Cloning and Stem Cells

Stem cells and cloning are both controversial topics in the news. How do they really work? What is the science behind these genetic procedures, and what are their implications for us?

31 min
Genetics and Agriculture
23: Genetics and Agriculture

Just three crops-corn, rice, and wheat-make up two-thirds of the world's food supply. Learn in this lecture how genetic experimentation on grains has resulted in significant increases in crop yields, which has meaningful ramifications for feeding the world's hungry.

30 min
Biotechnology and Agriculture
24: Biotechnology and Agriculture

Changes in our environment affect the plants we grow and thus the food we eat. Biotechnology has enabled us to manipulate plants to adapt to different conditions, such as tomatoes that grow in salty soil. This final lecture explores the opportunities and controversies surrounding genetically modified plants.

31 min
David Sadava

The DNA double helix, discovered in 1953, is one of the great icons of science in our society, rivaling the atom in its pervasiveness in our culture.

ALMA MATER

University of California, San Diego

INSTITUTION

City of Hope Medical Center, Claremont Colleges

About David Sadava

Dr. David Sadava is Adjunct Professor of Cancer Cell Biology at the City of Hope Medical Center in Duarte, CA, and the Pritzker Family Foundation Professor of Biology, Emeritus, at The Claremont Colleges. Professor Sadava graduated from Carleton University as the science medalist with a B.S. with first-class honors in biology and chemistry. A Woodrow Wilson Fellow, he earned a Ph.D. in Biology from the University of California, San Diego. Following postdoctoral research at the Scripps Institution of Oceanography, he joined the faculty at Claremont, where he twice won the Huntoon Award for Superior Teaching and received numerous other faculty honors. He has been a visiting professor at the University of Colorado and at the California Institute of Technology. Professor Sadava has held numerous research grants and written more than 55 peer-reviewed scientific research papers, many with his undergraduate students as coauthors. His research concerns resistance to chemotherapy in human lung cancer, with a view to developing new, plant-based medicines to treat this disease. He is the author or coauthor of five books, including the recently published 10th edition of a leading biology textbook, Life: The Science of Biology, as well as a new biology textbook, Principles of Life.

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